jeanelle leeland: Resveratrol New | Gnet Health and Fitness

Resveratrol, A Miracle in Modern Times!

Resveratrol is a true miracle of our times. It possesses an amazing spectrum of benefits including anti-obesity, anti-aging, cardioprotective, anticancer, anti-inflammatory and antioxidant properties ?. all in one! Truly Amazing!
Resveratrol (trans-3,5,4-trihydroxystilbene) belongs to the chemical class of stilbenes. It is largely present in the skins of red grapes from which red wine is made. 3-5 glasses of red wine contain about 75-125mg of resveratrol.
Resveratrol is a phytoalexin, a class of antibiotic compounds produced as a part of a plant?s defense system against disease or an invading fungus.
Traditionally it is a component of Ko-jo-kon, or japnese knotweed (Polygonnum cuspidatum), which has been used to treat diseases of the blood vessels, heart and liver in oriental medicine.
Resveratrol came into the spot-light as an explanation for the ?French Paradox? ? the low incidence of heart disease among the French people, who eat a relatively high-fat diet but drink lots of red wine.
Research has uncovered a diverse range of properties that may make resveratrol one of the most useful agents ever discovered for a wide range of human health problems.

Sources of Resveratrol

In this Excellent Video Dr. Oz Discusses about how to lose weight and the risks associated with being overweight.

This video discusses the extraordinary benefits of Resveratrol.

Multiple Benefits of Resveratrol and Its Mode of Action.

How Resveratrol helps you to lose Weight

Sirtuin 1 or Sirt1 is a gene which codes for the production of protein family called Sirtuin. These are responsible for sensitivity of body cells to insulin.
Reseveratrol is a potent activator of the Sirt1 gene. It increases insulin sensitivity of body cells and makes them take up more glucose (which is good for us).
In this way less glucose is available to be stored as fat and more fat is broken down into glucose to keep up the supply of glucose to the body cells.
If you are on a diet, your body has no choice but to use breakdown fat to get glucose. Using resveratrol during diet will speed up this process and you will lose fat (and weight) faster.

Resveratrol as an anti-obesity agent

Resveratrol inhibits fat cell proliferation and formation of adipose tissues.
Resveratrol also mediates changes in adipokine secretion. Adipokines are hormones which are produced by fatty cells. They are involved in multiple pathological processes and are directly linked to obesity-related health problems.Thus resveratrol can reduce obesity linked diseases such as Diabetes.
Resveratrol influences adipose tissue mass and function. It interferes with the development of obesity-related comorbidities. Thus resveratrol could be used for prevention or treatment of obesity-associated disorders.

How Resveratrol protects you from heart diseases

Lipids such as cholesterol are harmful for your cardiac health. They are partly responsible for diseases such as hyperlipidemia, atherosclerosis and heart attack.
Resvertrol inhibits the expression of a lipogenic gene which is responsible for formation of lipids. Thus it reduces the amount of lipids formed by your body (your body synthesizes its own cholesterol daily) and reduces the chance of cardiovascular diseases.
Resveratrol also reduces platelet aggregation (just like aspirin). This contributes to prevention of atherosclerosis ? which is a major cause of heart attack!

How Resveratrol acts as anti-aging and improves longevity

The Sirt 1 gene is partly linked to longevity according to studies on yeasts, worms and fish.
Caloric or diet restriction, a phenomenon of limiting your calories or diet, leads to slowing of the aging processes and longer life in many organisms.
This restriction cannot be applied to humans because it is not practically possible to limit our diet for our whole lives, so we cannot take advantage of this naural phenomenon.
However resveratrol mimics this effect of caloric restriction; partly through activation of Sirt1 gene. This produces sirtuin (protein) that changes the chemistry in your body to help neutralize aging and age-related diseases.
The New York Times reports that a researcher, David Sinclair, was taking resveratrol himself and founded Sirtris Pharmaceuticals to develop chemicals that mimic the role of resveratrol. GlaxoSmithKline acquired Sirtris Pharmaceuticals for $720 million in 2007 and hopes to develop ?drugs that target the sirtiuns which are associated with the aging process!?

How Resveratrol acts as an Anti-Inflammatory and Anti-Pyretic (anti-fever) agent

Resveratrol inhibits the secretion of interleukin-6 and interleukin-8. These are cellular messengers which are responsible for causing inflammation and fever. This merits the use of Resveratrol in inflammatory diseases such as arthritis.

How Resveratrol Prevents and Cures Cancer

Resveratrol possesses a fascinating spectrum of pharmacologic properties. Multiple biochemical actions contribute to its effects against precancerous and cancerous cells.
Resveratrol affects all three stages of carcinogenesis i.e .the initiation, promotion, and progression of cancer by modulating signal transduction pathways.
Resveratrol acts as an antioxidant and antimutagen. It means that it does not allow normal cells to mutate (change) into cancer cells. i.e It prevents the initiation of cancer.
It mediates anti-inflammatory effects and inhibits cyclo-oxygenase and hydroperoxidase functions which are invloved in promotion of cancer.
It induces human promyelocytic leukemia cell differentiation which inhibits the progression of cancer.
In addition, it inhibits the development of pre-cancerous cells and thus inhibits the formation of tumors.

Resveratrol as an Anti-Oxidant

Resveratrol has antioxidant properties. It inhibits free radical formation and provides more effective protection than other well-known antioxidants, such as vitamins C and E.

Resveratrol as a Phyto-Estrogen

Phytoestrogens are those compounds which come from plant source (phyto) and bear resemblance to estrogen, the major female hormone which regulates menstrual cycle.
Resveratrol is a phytoestrogen that interacts with estrogen receptors. This interaction inhibits cancer formation and growth, reduces cholesterol levels, and show benefits in treating osteoporosis.

Side Effects & Contraindications ? Caution Advised !

Dangers of consumption of alcohol present in the wine.

Alcohol is a proven carcinogen, and those who drink have significantly higher rates of brain, esophageal, liver, breast, and other cancers. About one-third of heavy drinkers eventually develop peripheral neuropathy ? a painful condition not relieved by typical painkillers.

Adverse Effects of Resveratrol

Resveratrol is not known to be toxic or cause adverse effects in humans but the toxicity data available is limited. Recent research found that a single dose up to 5 grams resulted in no serious adverse effects

Use in Pregnancy and Lactation

There is no data available for safety of resveratrol during pregnancy and lactation. So pregnant or lactating women should practice caution and consult doctor during use of resveratrol supplements. Pregnant women should totally avoid consuming wine as a source of resveratrol.

Estrogenic Effects

Women with a history of estrogen-sensitive cancers, such as breast, ovarian, and uterine cancers, should avoid taking high dose resveratrol supplements.

Drug Interactions ? Anticoagulant and Antiplatelet Drugs

Resveratrol inhibits platelet aggragation just like aspirin. So high intakes of resveratrol (e.g., from supplements) could increase the risk of bleeding when taken with anticoagulant drugs, such as warfarin (Coumadin) and antiplatelet drugs, such as clopidogrel.

In Short you should not consume high quantities of anything, including resveratrol, that does not have an established safety profile.

Popuplar News Papers Confirm the Beneficial effects of Resveratrol

Resveratrol in BBC News

Resveratrol in Fox News

Research studies confirm the extra ordinary benefits of Resveratrol!

?Resveratrol influences adipose tissue mass and interferes with the development of obesity-related co-morbidities. Thus resveratrol could prevent or treat obesity-associated disorders.? (http://www.ajcn.org/content/92/1/5)
?Results suggest that resveratrol is a molecule with potential anti-obesity effect. It significantly reduced mesenteric and subcutaneous fat depots.? (http://www.springerlink.com/content/j42757x52n8t2263)
?Daily consumption of resveratrol, may reduce body fat levels by preventing formation of fat tissue.? (http://www.ncbi.nlm.nih.gov/pubmed/21569266)
?Resveratrol extends the lifespan and significantly increases the survival ? through increased insulin sensitivity and improved motor function. Resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly.? (http://www.nature.com/nature/journal/v444/n7117/full/nature05354.html)
?Resveratrol was shown to have anti-cancer activity in three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen. This suggests that resveratrol merits as a potential cancer chemopreventive agent in humans.? (http://www.sciencemag.org/content/275/5297/218.abstract)

Reviews of people who have used Resveratrol

Lost 27 lbs and Excited for the 30 lb Mark.

Just wanted to let you know that I hit a plateau for a bit and then the weight loss went explosive again. I?ve now lost 27 lbs and am excited for the 30 lb mark. In a few pounds I become non-obese which is a mile marker for me. The Body Mass Index has shown that I have been obese for the last few years. So I will soon just be in the overweight bunch and then soon I will be truly slim and trim. I?m going for it with everything I?ve got now. That Bio Shape is pretty awesome stuff!

? William Lucas

This is wild for me?.

I didn?t lose any weight for the first 12 days on resveratrol But then it sort of ?caught on?and I?ve lost 11 lbs in 11 days, 1 lb at a time. That is just awesome to me ? thank you for a great, healthy weight loss product!

? William, New Smyrna Beach, Florida.

I Truly Feel This is Worth the Money!

I am an admitted emotional eater but after taking resveratrol I was able to suppress my appetite more than I would have been able to without it. I truly feel this is worth the money. I had no negative side effects and actually felt better when I was taking it. The only discomfort was the dry mouth I experienced, however, I wouldn?t deem it negative because it forced me to drink more water!

? V, United States.

My Measures Have Become Stable!

As a diabetic (type 2) I?ve experienced amazing results. My labs have been problematic for years with very high values. After taking Resveratrol the labs have become stable on a low level. I also have been able to reduce my insulin units.

? Lars, Norway.

Proven Results!

Before taking Resveratrol I was tested and my cholesterol was 236. After taking Resveratol for a year my results dropped to 116! No drugs! No change in diet! I?ve also dropped 13 pounds without any real effort.

? David C.

jeanelle leeland

Friday, August 3, 2012

Resveratrol New | Gnet Health and Fitness